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Contents

Volume 1

Section I: Biophysical and technical principles

Chapter 1 - Basic principles that determine relationships between pulsatile hemodynamic phenomena and function of elastic vessels     Pages 3-26

Chapter 2 - Measurements of arterial pressure and flow in vivo    Pages 27-47

Chapter 3 - Essential principles of pulsatile pressure-flow relations in the arterial tree   Pages 49-66

Chapter 4 - MRI for the assessment of aortic stiffness and pulsatile hemodynamics  Pages 67-76

Chapter 5 - Computed tomography of the aorta Pages 77-90

Chapter 6 - Radionuclide-based imaging of the aortic wall     Pages 91-109

Chapter 7 - Arterial wall stiffness: basic principles and methods of measurement in vivo   Pages 111-124

Chapter 8 - Ambulatory measurement of pulsatile hemodynamics     Pages 125-135

Chapter 9 - Animal models and methods to study arterial stiffness     Pages 137-151

Section II: Basic and applied physiology

Chapter 10 - Hemodynamic role of the aorta     Pages 155-168

Chapter 11 - Wave reflection in the arterial tree     Pages 169-194

Chapter 12 - Linking arterial stiffness to microvascular remodeling     Pages 195-209

Chapter 13 - Myocardial function: from myofilaments to cardiac pump  Pages 211-225

Chapter 14 - Systolic–diastolic coupling    Pages 227-240

Chapter 15 - Ventricular–arterial coupling: the pressure–volume plane   Pages 241-254

Chapter 16 - Myocardial wall stress and the systolic loading sequence    Pages 255-268

Chapter 17 - Assessment of ventricular arterial interactions via arterial pressure-flow relations in humans    Pages 269-279

Chapter 18 - Hemodynamic determinants of myocardial oxygen demand and supply    Pages 281-295

Section III: Biologic pathways leading to arterial stiffness and dysfunctional pulsatile hemodynamics

Chapter 19 - Role of elastin and elastin-derived peptides in arterial stiffness: from synthesis to potential therapeutic interventions    Pages 299-313

Chapter 20 - Inflammation and arterial stiffness    Pages 315-325

Chapter 21 - Mechanisms of calcification in the aortic wall and aortic valve    Pages 327-340

Chapter 22 - Vascular smooth muscle cell dysfunction: role in arterial stiffening and cardiovascular disease    Pages 341-357

Chapter 23 - Endothelial cell dysfunction and senescence: biologic mechanisms and hemodynamic consequences    Pages 359-367

Chapter 24 - Autonomic and neuroendocrine modulation of arterial stiffness and hemodynamics

Pages 369-390

Chapter 25 - Cellular mechanisms of aging and their impact on the aortic/arterial wall    Pages 391-405

Volume 2

Section IV: Clinical significance of arterial stiffness and pulsatile hemodynamics

Chapter 26 - Normal aging: arterial stiffness and remodeling over the life course    Pages 409-419

Chapter 27 - Early vascular aging and supernormal vascular aging: genetics, epigenetics, and the environment    Pages 421-428

Chapter 28 - Ethnic differences in arterial stiffness and central aortic hemodynamics    Pages 429-443

Chapter 29 - Arterial stiffness and pulsatile hemodynamics in systemic hypertension    Pages 445-455

Chapter 30 - Arterial stiffness and pulsatile hemodynamics in diabetes and obesity    Pages 457-469

Chapter 31 - Cardiovascular risk prevention in clinical medicine: current guidelines in the United States and in Europe    Pages 471-490

Chapter 32 - Cardiovascular risk prevention in clinical medicine: current guidelines in Asia    Pages 491-501

Chapter 33 - Arterial stiffness for cardiovascular risk stratification in clinical practice    Pages 503-525

Chapter 34 - Role of the heart and arterial tree in physiologic adjustments during exercise   Pages 527-544

Chapter 35 - Invasive hemodynamic assessments during exercise: normal patterns and clinical value     Pages 545-563

Chapter 36 - Arterial stiffness and pulsatile hemodynamics in heart failure    Pages 565-589

Chapter 37 - Ventricular–arterial coupling and arterial load in aortic valve disease    Pages 591-607

Chapter 38 - Arterial stiffness and atherosclerosis: mechanistic and pathophysiologic interactions

Pages 609-620

Chapter 39 - Arterial stiffness and pulsatile hemodynamics in coronary artery disease and other forms of atherosclerotic vascular diseases    Pages 621-635

Chapter 40 - Arterial stiffness and pulsatile hemodynamics in renal disease    Pages 637-647

Chapter 41 - Arterial stiffness, pulsatile hemodynamics, and the vascular contributions to dementia    Pages 649-663

Chapter 42 - Arterial stiffness and pulsatile hemodynamics in pregnancy and pregnancy-related vascular complications    Pages 665-687

Chapter 43 - Arterial stiffness and pulsatile hemodynamics in pediatric populations    Pages 689-706

Chapter 44 - Aortopathies and arteriopathies    Pages 707-712

Chapter 45 - Arterial stiffness and pulsatile hemodynamics in thoracic aortopathies   Pages 713-726

Chapter 46 - Arterial stiffness and pulsatile hemodynamics in congenital heart disease   Pages 727-748

Chapter 47 - Infection and arterial stiffness    Pages 749-769

Chapter 48 - Arterial stiffness, hemodynamics, and microvascular complications in conditions characterized by low arterial pulsatility    Pages 771-779

Section V: Therapeutic approaches to improve arterial stiffness and pulsatile hemodynamics

 Chapter 49 - Effects of common antihypertensive treatments on pulsatile arterial hemodynamics

Pages 783-793

Chapter 50 - Pharmacologic approaches to reduce arterial stiffness    Pages 795-806

Chapter 51 - Organic and dietary nitrates, inorganic nitrite, nitric oxide donors, and soluble guanylate cyclase stimulation    Pages 807-828

Chapter 52 - Effect of exercise training and weight loss on arterial stiffness and pulsatile hemodynamics    Pages 829-849

Chapter 53 - Dietary salt and arterial stiffness    Pages 851-864

Chapter 54 - Role of arterial stiffness and central hemodynamics in personalized medicine in hypertension   Pages 865-879

Section VI: Arterial stiffness and pulsatile hemodynamics in the pulmonary circulation

Chapter 55 - Pulsatile hemodynamics and ventricular–arterial interactions in the pulmonary circulation: physiologic concepts   Pages 883-897

Select Chapter 56 - Pulmonary arterial load and ventricular–arterial coupling in pulmonary hypertension    Pages 899-915

Chapter 57 - Biologic mechanisms and consequences of pulmonary artery stiffening in pulmonary hypertension   Pages 917-934

Chapter 58 - Therapeutic approaches to improve pulmonary arterial load and right ventricular–pulmonary arterial coupling    Pages 935-958

Index    Pages 959-982

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