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فهرست مطالب: Preface....... . . . . . . vContributors........ . ix Contents 1 Library Synthesis: Building Block Selection, Handling, and Tracking...... . . . . . 1 Katelyn J. Billings and Melissa C. Grenier-Davies 2 Library Synthesis: Building Block Validation... . . . . 13 Melissa C. Grenier-Davies 3 Library Synthesis and Analytics.... . . . . . . . 17 Jing Chai 4 Chemical Ligation of Oligonucleotide Tags to Support Encoded Chemical Library Synthesis...... . 25 Alexander Litovchick and Anthony D. Keefe 5 On-DNA Reductive Amination and Alkylation... . . 33 Jing Chai 6 On-DNA-1,2,3-Triazole Formation via Click Reaction.. . . . . 39 Sarah K. Scott 7 On-DNA Suzuki-Miyaura Cross-Coupling... . . . . . . 45 Yun Ding 8 On-DNA Pd and Cu-Promoted C-N Cross-Coupling Reactions.. . . . . 49 Xiaojie Lu and Xuan Wang 9 Palladium-Promoted On-DNA Heck Reactions.... . 55 Xuan Wang and Xiaojie Lu 10 Ruthenium-Promoted On-DNA C-H Activation Reaction... 63 Xuan Wang and Xiaojie Lu 11 DNA-Compatible Nitro Reduction and Synthesis of Benzimidazoles...... 67 Huang-Chi Du, Ying-Chu Chen, and Hongbing Huang 12 Condensation of DNA-Conjugated Imines with Homophthalic Anhydride for the Synthesis of Isoquinolones On-DNA.. . . . 75 Josephine Yuen, Jing Chai, and Yun Ding 13 DNA Encoding of Natural Products.... . . 81 Hongtao Xu and Peixiang Ma 14 Initiating DNA-Encoded Library Synthesis with a Hexathymidine DNA Oligonucleotide...... . . . . . 89 Mateja Klika Sˇkopic´, Denise dos Santos Smith, Anne Gohla, Verena B. K. Kunig, and Andreas Brunschweiger 15 One Bead-One Compound (OBOC) Peptidomimetic-Encoded Library Synthesis via Split-and-Pool Methods... . . . 105 Claudio Aquino and Mohosin Sarkar vii viii Contents 16 DNA Conjugates as Tool Compounds for DEL Selections... 121 David I. Israel 17 Quantitation of DNA-Encoded Libraries by qPCR.. . . . . . . . 135 Christopher S. Kollmann 18 Target Protein Design and Preselection Analysis... . 143 Qiuxia Chen and David I. Israel 19 DEL Selections Against a Soluble Protein Target... 155 Qiuxia Chen and Junyang Zhu 20 Selection Method of DNA-Encoded Chemical Library for Irreversible Covalent Binders...... . 165 Zhengrong Zhu 21 Next Generation Sequencing of DNA-Encoded Libraries.. . . 173 Jian Liu and You Li 22 Translation of DNA Sequence to Chemical Structure in DNA-Encoded Libraries...... . 187 You Li 23 Analysis of DNA-Encoded Library Screening Data: Selection of Molecules for Synthesis..... . . 195 Alexander L. Satz and Weiren Cui 24 High-Throughput Binder Confirmation (HTBC)... . . . . . . . . 207 Bing Xia and Jennifer D. Summerfield 25 High-Throughput Binder Confirmation Using Affinity Selection Mass Spectrometry...... . . . . . . . . 215 Eric X. Shi Index....... . . . . . . . 225 مشخصات فایل |
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| عنوان (Title): | DNA-Encoded Chemical Libraries_ Methods and Protocols |
| نام فایل (File name): | 939-www.GeneProtocols.ir-DNA-Encoded Chemical Libraries_ Methods and Protocols-Humana (2022).pdf |
| عنوان فارسی (Title in Persian): | کتابخانه های شیمیایی رمزگذاری شده با DNA- روشها و پروتکل ها |
| ایجاد کننده: | David Israel (editor), Yun Ding (editor) |
| زبان (Language): | انگلیسی English |
| سال انتشار: | 2022 |
| شابک ISBN: | 1071625446, 9781071625446 |
| نوع سند (Doc. type): | کتاب |
| فرمت (File extention): | |
| حجم فایل (File size): | 9.40 مگابایت |
| تعداد صفحات (Book length in pages): | 225 |
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برچسب ها:
2022,
انگلیسی,
بیوانفورماتیک,
توالی یابی,
دی ان ای,
پروتکل,
پروتکل آزمایشگاهی,
پروتکل بیوشیمی,
پروتکل ژنتیک,
ژنومیکس,
